{"id":1260,"date":"2018-01-30T06:38:09","date_gmt":"2018-01-30T11:38:09","guid":{"rendered":"https:\/\/medicinalherbals.net\/?p=1260"},"modified":"2024-01-07T11:47:49","modified_gmt":"2024-01-07T16:47:49","slug":"fucoidan","status":"publish","type":"post","link":"https:\/\/medicinalherbals.net\/fucoidan\/","title":{"rendered":"Fucoidan: Japans Best Kept Secret – A Potential Supplement for Cancer"},"content":{"rendered":"\n

What is Fucoidan?<\/strong><\/h2>\n\n\n\n

Fucoidan refers to a type of polysaccharide<\/a>, characterized by significant amounts of l-fucose and sulfate ester groups, which is typically found within brown seaweed and some other marine invertebrates (such as sea cucumber). Brown algae variants that contain fucoidan include kombu, bladderwrack, hijiki, wakame, limmoui, and mozuku, to name a few. The substance was initially discovered as a constituent of marine brown algae in 1913, when Swedish botanist Harald Kylin was first able to isolate fucoidan from seaweed. The types of brown seaweeds containing fucoidan are commonly found in East Asia, and are consumed regularly as a staple of the normal diet in Japan, China, and Korea. Though they possess similar properties, these seaweeds can differ greatly in appearance. For example, bladderwrack is actually a muddy green color, with long, strap-like fronds that tend to drape over intertidal stones and rocks. Conversely, kombu (the \u201cKing Seaweed\u201d) is comprised of long, thin strips of dark kelp, greenish when dried and very commonly used to make Dashi broth in Japanese cuisine.<\/p>\n\n\n\n

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Our Favorite Fucoidan on the market!<\/p><\/div><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/grammarly-extension><\/div>

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Over the past half a century or so, there has been much interest in the immunologic, metabolic, and anti-metastatic benefits fucoidan may have on the human body. Fucoidan is an AMPK Activator which regulates cellular energy homeostasis.<\/a> It’s also rich in calcium, iodine, zinc, iron, vitamin A, and selenium, and is touted by some to be a \u201cmiracle\u201d supplement. In fact, since 1970 fucoidan has been researched and cited in approximately 1,400 studies published by the United States National Library of Medicine.<\/p>\n\n\n\n

Fucoidan Benefits and Uses<\/strong><\/h2>\n\n\n\n

Fucoidan has been the subject of several recent studies, particularly in relationship to its anti-tumor and anti-metastatic activities, which are known to directly inhibit the growth and proliferation of cancer cells. Further, fucoidan is believed to demonstrate numerous other health benefits, including increased immune defense functionality and possible obesity prevention.<\/p>\n\n\n\n

Lung Cancer<\/strong><\/h3>\n\n\n\n

Laboratory evidence has demonstrated fucoidan to be effective in the treatment of various types of cancers, including lung cancer\/carcinoma and breast cancer. A recent study at Gyeongsang National University determined that the algae-based polysaccharide has an anti-metastatic mechanism (with metastasis referring to the pathogenic spread of a cancerous tumor), meaning fucoidan has the capability to inhibit the growth and spread of cancerous cells. Specifically, fucoidan was demonstrated to have an anti-metastatic effect on A549 lung cancer cells at a concentration of 400 \u00b5g\/ml. The study was conducted using the Western Blot technique, which separates and identifies proteins based on molecular weight and gel electrophoresis. While many clinical trials testing the anti-cancer and anti-tumor capabilities of fucoidan have been conducted with laboratory rats and mice, this particular study is a direct indicator that fucoidan inhibits the metastatic invasion of lung cancer cells in humans.<\/p>\n\n\n\n

Lymphoma<\/strong><\/h3>\n\n\n\n

Based on clinical trials and laboratory research presented at the AACR Dead Sea International Conference on Advances in Cancer Research in 2010, researchers believe there is promise that fucoidan may come forth as an effective lymphoma treatment within the next several years. The major sulfated polysaccharide has been demonstrated to inhibit the growth of malignant DLBCL lymphatic cell lines, while leaving healthy cells functional and intact. Further, a 2015 clinical study published by the Acta Biochimica et Biophysica Sinica <\/em>(ABBS) journal of biochemistry and cell biology found that fucoidan treatment halted G0\/G1 cell cycles, meaning tumor cells were prevented from dividing, reproducing, and proliferating in diffuse large B-cell lymphoma. This study was conducted in vitro and in vivo, utilizing cell culture techniques, Western Blot analysis, cell cycle analysis, and tumor xenograft modeling.<\/p>\n\n\n\n

Breast Cancer<\/strong><\/h3>\n\n\n\n

Fucoidan\u2019s anti-tumor functions are also visible in the treatment and\/or prevention of breast cancer. In a recent (March 2012) study also published by the Public Library of Science, fucoidan was found to considerably decrease the number of functional malignant 4T1 cells (breast cancer cells) in laboratory mice, directly reducing the volumes and weights of existing tumors. The tests were performed both in vitro and in vivo. In another study published by the Japanese Journal of Cancer Research, powdered mekabu (one of the many brown seaweeds from which fucoidan can be extracted) had demonstrated to have an exceptionally strong preventative effect on mammary carcinogenesis in rats when consumed in daily drinking water.<\/p>\n\n\n\n

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Here’s a list of the Best Fucoidan on the Market Today<\/a><\/div>\n<\/div>\n\n\n\n

Weight Loss<\/strong><\/h3>\n\n\n\n

Fucoidan is effective in the prevention and\/or treatment of obesity, and thus is likely to be useful towards generalized weight loss efforts. In a 2011 in-vitro study conducted in South Korea, fucoidan was found to aid in the stimulation of lipolysis, or the systematic breakdown of fats and lipids in treated cells. In a concentration of 200 \u03bcg\/mL, fucoidan demonstrated high rates of lipid inhibition, particularly in relationship to hormone-sensitive lipase, which converts stored triglycerides into free fatty acids.<\/p>\n\n\n\n

Hair<\/strong><\/h3>\n\n\n\n

Fucoidan is known to promote the regeneration of hair cells even after cell damage or even stimulated hair cell death. In a study published by Hearing Research, three different types of transgenic zebrafish hair cell lines were allowed to fertilize and then were eliminated using neomycin. Subsequently the larvae were treated with low-molecular weight fucoidan, which stimulated the regeneration of hair cells (as well as their peripheral supporting cells) much faster than was seen in non-treated controls.<\/p>\n\n\n\n

Diabetes<\/strong><\/h3>\n\n\n\n

In a very recent study, conducted in April of 2017 for the Marine Drugs open access journal (which researches marine natural product chemistry), fucoidan demonstrated three significant mechanisms beneficial to the management of Type II Diabetes; at low molecular weights it can be antihyperglycemic, antihyperlipidemic, and hepatoprotective. Research was conducted on mice that exhibited high body weights and blood sugar levels due to an abnormality in their leptin receptors. In other words, they exhibited symptoms similar to those of diabetes in overweight humans. Results found that fucoidan extract implementation increased hepatic glycogen and antioxidative enzymes when combined with fucoxanthin (or Fx, a nutritional carotenoid also found in brown seaweed). Fucoidan actually outperformed Fx in terms of improving hepatic (liver) glucose metabolism. Studies such as these indicate that fucoidan can help prevent diabetic symptoms by lowering high blood glucose levels, stimulating improved function of insulin production, and boosting digestive function.<\/p>\n\n\n\n

Candida<\/strong><\/h3>\n\n\n\n

Fucoidan extracted from bladderwrack, a common type of seaweed found on the shores of the North Sea, the Baltic Sea, and the Atlantic and Pacific Oceans, has been found to inhibit the growth of malignant bacteria and viruses, including human cytomegalovirus and herpes simplex virus. In a study conducted at the Center of Excellence in Generative Medicine at the University of Bridgeport (Connecticut, USA), bladderwrack was also found to enhance cell adhesion in several strains of the pathogenic yeast Candida, thereby preventing the cells from reproducing and spreading.<\/p>\n\n\n\n

Arthritis<\/strong><\/h3>\n\n\n\n

Fucoidan has shown promising results when it comes to treating arthritis. In a 2015 study on rats that were induced with osteoarthritis, fucoidan showed considerable improvement at preventing the progression of osteoarthritis. Although encouraging the natural leap to human trials needs to be taken in order to further prove its use for arthritis.