{"id":2918,"date":"2021-09-01T14:44:36","date_gmt":"2021-09-01T19:44:36","guid":{"rendered":"https:\/\/medicinalherbals.net\/?p=2918"},"modified":"2024-01-07T11:33:41","modified_gmt":"2024-01-07T16:33:41","slug":"indole-3-carbinol","status":"publish","type":"post","link":"https:\/\/medicinalherbals.net\/indole-3-carbinol\/","title":{"rendered":"Indole-3-Carbinol (I3C) Supplementation: Benefits, Side Effects & Dosage"},"content":{"rendered":"\n
Indole-3-Carbinol (I3C) is a derivative of glucobrassicin, a type of glucosinolate that can be found in cruciferous vegetables such as cabbages, broccoli, and mustards [i]<\/sup><\/a>. In mammalian stomachs, I3C molecules undergo a type of condensation that is catalyzed by strong acids and that generates a number of biologically active components. The most active I3C oligomers (this refers simply to a relatively simple polymer with few repeating units) include 3,3\u2019-diindolylmethane (DIM) and 5,11-dihydroindolo-[3,2-b<\/em>]carbazole (ICZ) [ii]<\/sup><\/a>.<\/p>\n\n\n\n Numerous clinical and preclinical studies have strongly indicated that I3C and its oligomers have anti-estrogenic activity. As a result, there has been significant interest in the medical community in exploring the ways in which I3C might help reduce tumorigenesis in hormone-dependent cancers. Some more limited evidence from preliminary trials also points to I3C supplementation as possibly effective in the treatment of conditions related to human papillomavirus (HPV) infection, such as cervical\/vulvar intraepithelial neoplasias and recurrent respiratory papillomatosis [v]<\/sup><\/a>.<\/p>\n\n\n\n Other benefits of I3C supplementation are described in greater detail below, though it is important to note that further clinical research is needed to evaluate I3C\u2019s efficacy in relationship to other hypothesized therapeutic effects such as weight loss and lean muscle growth [vi]<\/sup><\/a>.<\/p>\n\n\n\n